Good morning and welcome to Thanksgiving week! STAT reporter Andrew Joseph right here filling in for Mr. Pharmalot at present. It’s my first Thanksgiving since transferring over to London to develop STAT’s European protection, however by no means concern, a Thanksgiving feast can be had on Thursday. (A reminder: It’s not too early to get began on some prep. I made my pie crusts over the weekend and they’ll dangle within the freezer for just a few days. Additionally, have you ever thought of how lengthy it takes to thaw your turkey?) Wishing these of you celebrating this week, wherever you’re, a contented vacation, and even when the massive day comes round however every year, it by no means hurts to remind your self what it’s you’re grateful for. Cheers!
4 CRISPR pioneers mirror in STAT on the approval of the world’s first CRISPR-based drugs and on the way forward for gene-editing therapies. Simply over a decade after their first CRISPR papers had been printed, Jennifer Doudna, Emmanuelle Charpentier, Feng Zhang, and George Church all chime in concerning the authorization of Casgevy within the U.Ok. for sickle cell and beta thalassemia. In addition they talk about the divergent paths they’ve taken over the previous 10 years, the promise of gene modifying, and the challenges that CRISPR must clear sooner or later.
The U.Ok. and the pharmaceutical business have reached a deal on a five-year plan outlining how the well being system pays for medication, because the nation tries to maintain a lid on its medicines spending whereas concurrently build up its life sciences business, STAT writes. The present plan, which has drawn the ire of pharma corporations, requires drug corporations to pay rebates again to the U.Ok. if spending on medicines will increase by greater than 2% a yr. Beneath the brand new settlement, the extent of allowed development in drug gross sales will improve from 2% in 2024 to 4% by 2027.